Nitric oxide and synaptic function.

@article{Schuman1994NitricOA,
  title={Nitric oxide and synaptic function.},
  author={Erin Margaret Schuman and Daniel V. Madison},
  journal={Annual review of neuroscience},
  year={1994},
  volume={17},
  pages={
          153-83
        }
}
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems. Whereas most neurotransmitters are packaged in synaptic vesicles and secreted in a Ca2+-dependent manner from specialized nerve endings, NO is an unconventional transmitter which is not packaged in vesicles, but rather diffuses from its site of production in the absence of any specialized release machinery. The lack of a… 

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References

SHOWING 1-10 OF 189 REFERENCES
Localization of nitric oxide synthase indicating a neural role for nitric oxide
TLDR
It is demonstrated that NO synthase in the brain to be exclusively associated with discrete neuronal populations, and prominent neural localizations provided the first conclusive evidence for a strong association of NO with neurons.
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
Nitric oxide synthase-independent long-term potentiation in area CA1 of hippocampus.
TLDR
The findings demonstrate that while NO is elevated with LTP-inducing stimuli, the activity of NO synthase is not necessary for induction of LTP by all stimulus paradigms, and support the hypothesis that NO can function as a transcellular messenger in the hippocampus.
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
TLDR
It is reported here that by acting on NMDA (N-methyl-D-aspartate) receptors on cerebellar cells, glutamate induces the release of a diffusible messenger with strikingly similar properties to EDRF that accounts for the cGMP responses that take place following NMDA receptor activation.
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.
TLDR
The macrophage enzyme is immunologically induced at the transcriptional level and closely resembles the enzyme in cytokine-treated tumor cells and inflammatory neutrophils.
An inhibitor of nitric oxide synthesis prevents memory formation in the chick
The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system.
TLDR
The hypothesis that the release of nitric oxide and its subsequent diffusion may be critically related to three aspects of nervous system function: synaptic plasticity and long-term potentiation in certain regions of the adult nervous system, the control of cerebral blood flow in such regions, and the establishment and activity-dependent refinement of axonal projections during the later stages of development is explored.
Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats.
TLDR
It is found that the NO synthase inhibitor N omega-nitro-L-arginine, at doses blocking LTP in hippocampal slices, impairs spatial learning in a radial arm maze and olfactory memory in a social recognition test, but left shock-avoidance learning unaffected.
Role of nitric oxide in NMDA-evoked release of [3H]-dopamine from striatal slices.
TLDR
It is found that exogenously applied NO evokes [3H]-dopamine release from cultured neurons, and a major role of endogenously-synthesized NO may be to evoke neurotransmitter release in local volumes of neural tissue.
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
TLDR
It is established that NO mediates the neurotoxicity of glutamate and Hemoglobin, which complexes NO, prevents neurotoxic effects of both N-methyl-D-aspartate and sodium nitroprusside.
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