Nitric oxide and synaptic function.

  title={Nitric oxide and synaptic function.},
  author={Erin Margaret Schuman and Daniel V. Madison},
  journal={Annual review of neuroscience},
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems. Whereas most neurotransmitters are packaged in synaptic vesicles and secreted in a Ca2+-dependent manner from specialized nerve endings, NO is an unconventional transmitter which is not packaged in vesicles, but rather diffuses from its site of production in the absence of any specialized release machinery. The lack of a… 

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Gases as neurotransmitters.
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