Nitric oxide and pulmonary hypertension.

  title={Nitric oxide and pulmonary hypertension.},
  author={Robert T Sperling and Mark A. Creager},
  journal={Coronary artery disease},
  volume={10 5},
The constitutive release of NO by the endothelium plays a key role in maintaining normal low basal pulmonary vascular tone and countering hypoxic vasoconstrictive tone in many mammals and in humans. Many, but not all, studies have suggested that reduced availability of NO contributes to the increased pulmonary vascular resistance that occurs in experimental models and in humans with pulmonary hypertension. Potential mechanisms limiting the activity of NO include L-arginine deficiency and a… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-3 of 3 extracted citations

Sarcoidosis-associated pulmonary hypertension: assessment and management.

Seminars in respiratory and critical care medicine • 2010
View 5 Excerpts
Highly Influenced