Nitric oxide and pregnancy.

  title={Nitric oxide and pregnancy.},
  author={Stefan Sladek and Ronald R Magness and Kirk P. Conrad},
  journal={The American journal of physiology},
  volume={272 2 Pt 2},
This review will consider whether nitric oxide (NO) contributes to maternal systemic vasodilation during pregnancy, regulates uterine and fetoplacental blood flow, and is involved in uterine quiescence prior to parturition. Also, whether a deficiency of NO contributes to the hypertensive disorder of pregnancy, preeclampsia, will be considered. The biosynthesis of NO increases in gravid rats and sheep, but the status in normal human pregnancy and preeclampsia is controversial. NO contributes to… CONTINUE READING