Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases.

@article{Napoli2009NitricOA,
  title={Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases.},
  author={Claudio Napoli and Louis Joseph Ignarro},
  journal={Archives of pharmacal research},
  year={2009},
  volume={32 8},
  pages={1103-8}
}
Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and leukocyte interactions with the arterial wall, regulation of vascular tone, proliferation of vascular smooth muscle cells, and homeostasis of blood pressure. Diminished NO bioavailability and abnormalities in NO-dependent signaling are among central factors of vascular disease, although it is unclear whether this is… CONTINUE READING