Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.

@article{Goodman2004NitricOA,
  title={Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.},
  author={Julie E. Goodman and Lorne J. Hofseth and S. Perwez Hussain and Curtis C. Harris},
  journal={Environmental and molecular mutagenesis},
  year={2004},
  volume={44 1},
  pages={3-9}
}
Nitric oxide (NO(.)), which is generated under chronic inflammatory conditions that predispose individuals to cancer, has paradoxical effects. NO(.) can activate p53, which can result in anti-carcinogenic effects, or it can be mutagenic and increase cancer risk. We explored the mechanisms by which NO(.) induced p53 activation in vitro and found that NO(.) induced p53 accumulation and phosphorylation, particularly at ser-15, via ATM and ATR kinases, which then led to cell cycle arrest at G(2)/M… CONTINUE READING

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