Nitric oxide and oxygen radicals: a question of balance.

  title={Nitric oxide and oxygen radicals: a question of balance.},
  author={Victor M. Darley-Usmar and Helen Wiseman and Barry Halliwell},
  journal={FEBS letters},
  volume={369 2-3},
The production of superoxide and nitric oxide individually has been associated with the development of several diseases but only recently has it been realised that interactions between them may also be important in disease pathology. The central hypothesis which is emerging is that the balance between nitric oxide and superoxide generation is a critical determinant in the aetiology of many human diseases including atherosclerosis, neurodegenerative disease, ischaemia-reperfusion and cancer… CONTINUE READING