Nitric oxide and nitroxidative stress in Alzheimer's disease.

  title={Nitric oxide and nitroxidative stress in Alzheimer's disease.},
  author={Tadeusz Malinski},
  journal={Journal of Alzheimer's disease : JAD},
  volume={11 2},
Nitric oxide is a signaling molecule produced by neurons and endothelial cells in the brain. NO is synthesized from L-arginine and oxygen by nitric oxide synthase: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS). The endothelial NO acts as a vasorelaxant in the vasculature and as a neurotransmitter when produced by neurons (under the pathological conditions of Alzheimer's disease). NO can be scavenged in a rapid reaction with superoxide (O2-) to generate peroxynitrite (ONOO-), with a… CONTINUE READING