Nitric oxide and mitochondrial status in noise-induced hearing loss.

  title={Nitric oxide and mitochondrial status in noise-induced hearing loss.},
  author={Xiaorui Shi and Weiju Han and Hiroshi Yamamoto and Irina Omelchenko and Alfred L. Nuttall},
  journal={Free radical research},
  volume={41 12},
The study investigated the distribution of nitric oxide (NO) within isolated outer hair cells (OHCs) from the cochlea, its relationship to mitochondria and its modulation of mitochondrial function. Using two fluorescent dyes--4,5-diamino-fluorescein diacetate (DAF-2DA), which detects NO, and tetramethyl rhodamine methyl ester (TMRM+), a mitochondrial membrane potential dye--it was found that a relatively greater amount of the DAF fluorescence in OHCs co-localized with mitochondria in comparison… CONTINUE READING


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