Nitric oxide and mitochondrial signaling: from physiology to pathophysiology.

  title={Nitric oxide and mitochondrial signaling: from physiology to pathophysiology.},
  author={Jorge D. Erusalimsky and Salvador Moncada},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={27 12},
Nitric oxide (NO) has been known for many years to bind to cytochrome C oxidase, the terminal acceptor in the mitochondrial electron transport chain, in competition with oxygen. This interaction may be significant in vivo and explain some of the biological actions of NO. In this article we review the evidence showing that binding of NO to cytochrome C oxidase elicits intracellular signaling events, including the diversion of oxygen to nonrespiratory substrates and the generation of reactive… CONTINUE READING
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