Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patients with age-related macular degeneration

@article{Everekliolu2003NitricOA,
  title={Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patients with age-related macular degeneration},
  author={Cem Evereklioğlu and Hamdi Er and Selim Doğanay and Mustafa Baki Çekmen and Yusuf Turkoz and Baris Otlu and Elif Ozerol},
  journal={Documenta Ophthalmologica},
  year={2003},
  volume={106},
  pages={129-136}
}
Background: Nitric oxide (NO), hydroxyl radical (OH.), superoxide anion (O2 −) and hydrogen peroxide (H2O2) are free-radicals released in oxidative stress. Superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase (CAT) are antioxidant enzymes, mediating defense against oxidative stress. Excess NO and/or defective antioxidants cause lipid peroxidation, cellular dysfunction and death. Age-related maculopathy (ARM) or degeneration (ARMD) is the leading cause of irreversible… CONTINUE READING
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