Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53.

@article{Cook2004NitricOA,
  title={Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53.},
  author={Tracy Cook and Zifa Wang and Sean Alber and Kaihong Liu and Simon C. Watkins and Yoram Vodovotz and Timothy R Billiar and David Blumberg},
  journal={Cancer research},
  year={2004},
  volume={64 21},
  pages={8015-21}
}
Nitric oxide (NO) is a potent tumor radiosensitizer; however, its clinical use is limited by systemic side effects. We have demonstrated previously that gene transfer of the human inducible NO synthase (iNOS) gene into tumor cells and tumors induces high-output NO production that significantly enhances tumor radioresponsiveness, with no observed side effects. Notably, iNOS gene transfer enhances tumor radioresponsiveness via apoptotic cell death. Because NO and ionizing radiation are both known… CONTINUE READING

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