Nitric oxide and cancer: the emerging role of S-nitrosylation.

  title={Nitric oxide and cancer: the emerging role of S-nitrosylation.},
  author={E. Rubio Aranda and Chary L{\'o}pez-Pedrera and Juan R. De la Haba-Rodr{\'i}guez and Antonio Rodr{\'i}guez-Ariza},
  journal={Current molecular medicine},
  volume={12 1},
Nitric oxide (NO˙) is a short-lived, endogenously produced gas that is highly diffusible across cell membranes and acts as a signaling molecule in the body. The redox state and chemistry of NO˙ facilitate its interaction with various proteins thus regulating various intracellular and intercellular events. One of the key mechanisms by which NO˙ regulates the function of various target proteins is through the coupling of a nitroso moiety from NO-derived metabolites to a reactive cysteine leading… CONTINUE READING
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