Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.

@article{Archer1994NitricOA,
  title={Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.},
  author={Stephen L Archer and James M-C Huang and V{\'a}clav Hampl and Daniel P Nelson and Pamela J. Shultz and Edward Kenneth Weir},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 16},
  pages={7583-7}
}
Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular smooth muscle cells. However, the mechanism by which cGMP causes relaxation is unknown. This study tested the hypothesis that activation of Ca-sensitive K (KCa) channels, mediated by a cGMP-dependent protein kinase, is responsible for the relaxation occurring in response to cGMP. In rat pulmonary artery rings, cGMP-dependent, but not cGMP-independent, relaxation was inhibited by tetraethylammonium, a… CONTINUE READING
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