Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells.

@article{Pilz1995NitricOA,
  title={Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells.},
  author={Renate B Pilz and Modem Suhasini and S D Idriss and Judy L. Meinkoth and Gerry R. Boss},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1995},
  volume={9 7},
  pages={552-8}
}
Nitric oxide (NO) increases cytosolic guanylate cyclase activity and thereby activates the cGMP signal transduction pathway. The cAMP and Ca2+/phospholipid signal transduction pathways activate transcription factors that bind to the cAMP response element (CRE) and phorbol ester response element (TRE), respectively. Little is known about transcriptional regulation of gene expression by NO/cGMP. In transient and stable transfection experiments and in microinjection studies we found that three… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Similar Papers

Loading similar papers…