Nitric oxide and cGMP activate Ca 2 +-release processes in rat parotid acinar cells

@inproceedings{LOOMSNitricOA,
  title={Nitric oxide and cGMP activate Ca 2 +-release processes in rat parotid acinar cells},
  author={Dagnia K. LOOMS and Katerina TRITSARIS and Birgitte NAUNTOFTE and Steen DISSING}
}
  • Dagnia K. LOOMS, Katerina TRITSARIS, +1 author Steen DISSING
We characterized the enzymic properties of ADP-ribosyl cyclase in rat parotid acinar cells by using a fluorescence technique. ADP-ribosyl cyclase is capable of synthesizing the Ca#+mobilizing nucleotide cADP-ribose (cADPR) from NAD+ and has previously been shown to be regulated by cGMP via a cGMP-dependent protein kinase (Gkinase).We therefore investigated whether NO}cGMP-activated pathways are present in rat parotid acinar cells and whether NO}cGMP signalling exerts control over cellularCa… CONTINUE READING