Nitric oxide activates p21ras and leads to the inhibition of endothelial NO synthase by protein nitration.

@article{Brennan2003NitricOA,
  title={Nitric oxide activates p21ras and leads to the inhibition of endothelial NO synthase by protein nitration.},
  author={Lisa A Brennan and Stephen Wedgwood and Janine M Bekker and S. M. Black},
  journal={DNA and cell biology},
  year={2003},
  volume={22 5},
  pages={317-28}
}
Recent data has indicated that exogenous nitric oxide (NO) has the ability to decrease endogenous NO production by inhibiting the enzyme responsible for its generation, NO synthase (NOS). Our previous studies have indicated that increased generation of reactive oxygen species (ROS) play an important role in the inhibitory event. However, the mechanisms for these effects remain unclear. Previous studies have suggested that NO can activate p21ras. Thus, the objective of this study was to… CONTINUE READING

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