Nitric oxide actions in paraventricular nucleus: cardiovascular and neurochemical implications.

@article{Horn1994NitricOA,
  title={Nitric oxide actions in paraventricular nucleus: cardiovascular and neurochemical implications.},
  author={Todd Horn and Pauline M. Smith and Brian E McLaughlin and L G Bauce and Gerald S. Marks and Quentin J Pittman and Alistair Ferguson},
  journal={The American journal of physiology},
  year={1994},
  volume={266 1 Pt 2},
  pages={R306-13}
}
We have examined potential functions of nitric oxide (NO) within the paraventricular nucleus (PVN) in urethan-anesthetized male Sprague-Dawley rats. Initial experiments demonstrated microinjection of 50 pmol of the NO donor, sodium nitroprusside (SNP), directly into the PVN resulted in significant decreases in mean blood pressure (BP) (-3,312 +/- 1,189 mmHg/s over 300-s response time; P < 0.05). To determine whether such effects were attributable to SNP-induced NO release, NO was administered… CONTINUE READING
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