Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle.

@article{LpezLpez2004NitricO,
  title={Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle.},
  author={Gustavo L{\'o}pez-L{\'o}pez and Laura Moreno and Angel Cogolludo and M E Mart{\'i}nez Galisteo and M. Socrates Ibarra and Juan Duarte and Federica Lodi and Juan Luis Tamargo and Francisco Perez-Vizcaino},
  journal={Molecular pharmacology},
  year={2004},
  volume={65 4},
  pages={851-9}
}
The flavonoid quercetin reduces blood pressure and endothelial dysfunction in animal models of hypertension. However, the results concerning the relationship between quercetin and NO present a complex picture. We have analyzed the mechanisms involved in the NO scavenging effects of quercetin and its repercussion on NO bioactivity in vascular smooth muscle. Quercetin scavenged NO with apparent zero-order kinetics with respect to NO. This effect was strongly dependent on the O(2) concentrations… CONTINUE READING

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The flavonoid quercetin reduces blood pressure and endothelial dysfunction in animal models of hypertension .
The flavonoid quercetin reduces blood pressure and endothelial dysfunction in animal models of hypertension .
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