Nitric oxide (NO) in normal and hypoxic vascular regulation of the spiny dogfish, Squalus acanthias.

@article{Swenson2005NitricO,
  title={Nitric oxide (NO) in normal and hypoxic vascular regulation of the spiny dogfish, Squalus acanthias.},
  author={Kai E Swenson and Randy L. Eveland and Mark T Gladwin and Erik R Swenson},
  journal={Journal of experimental zoology. Part A, Comparative experimental biology},
  year={2005},
  volume={303 2},
  pages={154-60}
}
Nitric oxide (NO) is a potent vasodilator in terrestrial vertebrates, but whether vascular endothelial-derived NO plays a role in vascular regulation in fish remains controversial. To explore this issue, a study was made of spiny dogfish sharks (Squalus acanthias) in normoxia and acute hypoxia (60 min exposure to seawater equilibrated with 3% oxygen) with various agents known to alter NO metabolism or availability. In normoxia, nitroprusside (a NO donor) reduced blood pressure by 20… CONTINUE READING