Nitric oxide: biosynthesis and biological significance.

  title={Nitric oxide: biosynthesis and biological significance.},
  author={Michael A Marletta},
  journal={Trends in biochemical sciences},
  volume={14 12},
The recent discovery that mammalian cells can synthesize nitric oxide coincided with the identification of this simple gas as a factor involved in cellular communication. Nitric oxide has now been shown to be derived from L-arginine in macrophages, endothelial cells and possibly other cell types. Its physiological role in macrophages may be as a cytotoxic agent. However, nitric oxide produced by endothelial cells is thought to trigger vascular smooth muscle relaxation through activation of the… CONTINUE READING

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