Nitric oxide: a regulator of eukaryotic initiation factor 2 kinases.

@article{Tong2011NitricOA,
  title={Nitric oxide: a regulator of eukaryotic initiation factor 2 kinases.},
  author={Lingying Tong and Rachel A Heim and Shiyong Wu},
  journal={Free radical biology & medicine},
  year={2011},
  volume={50 12},
  pages={1717-25}
}
Generation of nitric oxide (NO(•)) can upstream induce and downstream mediate the kinases that phosphorylate the α subunit of eukaryotic initiation factor 2 (eIF2α), which plays a critical role in regulating gene expression. There are four known eIF2α kinases (EIF2AKs), and NO(•) affects each one uniquely. Whereas NO(•) directly activates EIF2AK1 (HRI), it indirectly activates EIF2AK3 (PERK). EIF2AK4 (GCN2) is activated by depletion of l-arginine, which is used by nitric oxide synthase (NOS… CONTINUE READING

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