Nitric oxide/endothelin balance after nephron reduction.

  title={Nitric oxide/endothelin balance after nephron reduction.},
  author={Sistiana Aiello and Giuseppe Remuzzi and Marina Noris},
  journal={Kidney international. Supplement},
Nitric oxide (NO), an L-arginine derivative, is implicated in neuronal transmission, immune response and vasodilation, besides acting as a platelet function modulator. A number of recent studies in the experimental model of renal mass reduction (RMR) in rats have proposed the hypothesis that abnormalities of the NO synthetic pathway could have a key role in mediating the complex hemodynamic and hemostatic disorders associated with the progression of renal disease. Thus, renal NO generation is… CONTINUE READING
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