Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.

  title={Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.},
  author={Joseph S. Beckman and Willem H. Koppenol},
  journal={The American journal of physiology},
  volume={271 5 Pt 1},
Nitric oxide contrasts with most intercellular messengers because it diffuses rapidly and isotropically through most tissues with little reaction but cannot be transported through the vasculature due to rapid destruction by oxyhemoglobin. The rapid diffusion of nitric oxide between cells allows it to locally integrate the responses of blood vessels to turbulence, modulate synaptic plasticity in neurons, and control the oscillatory behavior of neuronal networks. Nitric oxide is not necessarily… 

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