Nitric oxide, N omega-hydroxy-L-arginine and breast cancer.

@article{Pervin2008NitricON,
  title={Nitric oxide, N omega-hydroxy-L-arginine and breast cancer.},
  author={Shehla Pervin and Rajan Singh and Gautam Chaudhuri},
  journal={Nitric oxide : biology and chemistry},
  year={2008},
  volume={19 2},
  pages={103-6}
}
Nitric oxide has varied effects on human breast cancer cells. At low concentration (micromolar range) it increases proliferation by increasing synthesis of some cells cycle protein and in higher concentration (nanomolar range) it leads to cytostasis or apoptosis by decreasing the translation of some cell cycle proteins. 

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Hypoxic inducible factor 1 alpha , extracellular signal - regulated kinase , and p 53 are regulated by distinct threshold concentrations of nitric oxide

  • R. L. Prueitt, B. J. Boersma, +11 authors S. Ambs
  • Proc . Natl . Acad . Sci . USA
  • 2004

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