Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria

@inproceedings{Ong2013NitricOS,
  title={Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria},
  author={Peng Kai Ong and Beno{\^i}t Melchior and Yuri Chaves Martins and Anthony Hofer and Pamela Orjuela-Sanchez and Pedro J. Cabrales and Graziela Maria Zanini and John A. Frangos and Leonardo Jos{\'e} de Moura Carvalho},
  booktitle={PLoS pathogens},
  year={2013}
}
Cerebrovascular dysfunction plays a key role in the pathogenesis of cerebral malaria. In experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA, cerebrovascular dysfunction characterized by vascular constriction, occlusion and damage results in impaired perfusion and reduced cerebral blood flow and oxygenation, and has been linked to low nitric oxide (NO) bioavailability. Here, we directly assessed cerebrovascular function in ECM using a novel cranial window method for… CONTINUE READING

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