Nitric Oxide Regulates Expression of Sonic Hedgehog and Hypoxia-Inducible Factor-1α in an Experimental Model of Kidney Ischemia-Reperfusion

@article{Ozturk2007NitricOR,
  title={Nitric Oxide Regulates Expression of Sonic Hedgehog and Hypoxia-Inducible Factor-1$\alpha$ in an Experimental Model of Kidney Ischemia-Reperfusion},
  author={H. Ozturk and M. Tuncer and H. Buyukbayram},
  journal={Renal Failure},
  year={2007},
  volume={29},
  pages={249 - 256}
}
This study was designed to determine the effect of L-arginine on hypoxia inducible factor alpha (HIF-1 α) and Sonic hedgehog (Shh) levels considered to be involved in the development of ischemia/reperfusion (I/R) injury. Unilaterally nephrectomized Sprague-Dawley rats were subjected to 60 minutes of left renal ischemia followed by 45 minutes of reperfusion. Group 1 were sham-operated animals; group 2, I-R/Untreated animals; and group 3, I-R/L-Arg-treated animals. Serum creatinine, blood urea… Expand
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