Nitric Oxide Modulates Cardiac Na Channel via Protein Kinase A and Protein Kinase

@inproceedings{Xu2001NitricOM,
  title={Nitric Oxide Modulates Cardiac Na Channel via Protein Kinase A and Protein Kinase},
  author={Yanfang Xu and Pei Hong Dong and Zhao Zhang and Jason P. Eiserich and Nipavan Chiamvimonvat},
  year={2001}
}
We directly tested the effects of nitric oxide (NO) on Na channels in guinea pig and mouse ventricular myocytes using patch-clamp recordings. We have previously shown that NO donors have no observed effects on expressed Na channels. In contrast, NO (half-blocking concentration of 523 nmol/L) significantly reduces peak whole-cell Na current (INa) in isolated ventricular myocytes. The inhibitory effect of NO on INa was not associated with changes in activation, inactivation, or reactivation… CONTINUE READING

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