Nitric-Oxide Mediated Effects of Transdermal Capsaicin Patches on the Ischemic Threshold in Patients with Stable Coronary Disease

  title={Nitric-Oxide Mediated Effects of Transdermal Capsaicin Patches on the Ischemic Threshold in Patients with Stable Coronary Disease},
  author={Gabriele Fragasso and Altin Palloshi and Pier Marco Piatti and Lucilla D. Monti and Enrico Rossetti and Emanuela Setola and Chiara Montano and Giorgio Bassanelli and G. Calori and Alberto Margonato},
  journal={Journal of Cardiovascular Pharmacology},
Background Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release. However, no data exist on its effect following systemic administration in humans. Methods Twelve male patients with stable coronary disease and a persistently positive exercise were selected for study. According to a double blind, placebo-controlled, cross-over study, patients were randomized to placebo or 3 g oleic capsaicin-containing patches, on 2… 

A Randomized, Placebo‐Controlled Study of the Effects of Telcagepant on Exercise Time in Patients With Stable Angina

The hypothesis that telcagepant does not reduce TET was supported if the lower bound of the two‐sided 90% confidence interval (CI) for the mean treatment difference (telcagespant–placebo) in T ET was more than −60 s.

A reactive oxygen species-mediated component in neurogenic vasodilatation.

In vivo evidence that ROS are involved in mediating TRPV1- and neuropeptide-dependent neurogenic vasodilatation is provided, and an essential role of NADPH oxidase-dependent ROS is revealed that may be of fundamental importance to the neurogenic Vasodilator component involved in circulatory homeostasis and the pathophysiology of certain cardiovascular diseases.

Dietary Capsaicin Protects Cardiometabolic Organs from Dysfunction

The habitual consumption of spicy foods was inversely associated with both total and certain causes of specific mortality after adjustment for other known or potential risk factors, and the enjoyment of spicy flavors in food was associated with a lower prevalence of obesity, type 2 diabetes, and cardiovascular diseases.

Capsaicin may have important potential for promoting vascular and metabolic health

In rodent studies, capsaicin-rich diets have shown favourable effects on atherosclerosis, metabolic syndrome, diabetes, obesity, non-alcoholic fatty liver, cardiac hypertrophy, hypertension and stroke risk and further clinical studies are needed to establish protocols that are tolerable for most patients, and to evaluate the potential of Capsaicin for promoting vascular and metabolic health.

Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation

This review focuses on vascular TRPV1 channels that are endogenously expressed in both vascular smooth muscle and endothelial cells and emphasizes the role of inflammation in sensitizing the TRpV1 channel to capsaicin activation.

CAP and Metabolic Diseases: A Mini Review on Preclinical Mechanisms and Clinical Efficacy

It is suggested that long-term safety and tolerance studies are important for advancing CAP to treat human obesity, as preclinical data from rodent model of high fat diet-induced obesity collectively suggest that CAP exerts its effects by activating TRPV1 signaling pathway, which leads to enhancement of metabolic activity and thermogenesis to counter obesity.

Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases

This review summarizes the historical background, source, structure and analogues of capsicin, and capsaicin-triggered TRPV1 signaling and desensitization processes and will focus on the therapeutic roles of Capsaicin and its analogues in both normal and pathophysiological conditions.

The effect of 4-week chilli supplementation on metabolic and arterial function in humans

Four weeks of regular chilli consumption has no obvious beneficial or harmful effects on metabolic parameters but may reduce resting heart rate and increase effective myocardial perfusion pressure time in men.



Effect of intravenous calcitonin gene related peptide on ischaemia threshold and coronary stenosis severity in humans.

Intravenous CGRP is a systemic arterial vasodilator which dilates coronary arteries at the site of atheromatous stenoses and delays the onset of myocardial ischaemia during treadmill exercise testing in patients with chronic stable angina.

Calcitonin gene-related peptide: a potent dilator of human epicardial coronary arteries.

Prior infusion of CGRP did not prevent coronary arterial spasm induced by ergonovine in two patients with variant angina, but a subsequent bolus of C GRP partially relieved the spasm.

Aggravation of myocardial infarction in the porcine heart by capsaicin-induced depletion of calcitonin gene-related peptide (CGRP).

This study indicates that peptides released from cardiac C fibers have a beneficial effect in myocardial ischemia and reperfusion and is a possible candidate for the mediation of the observed cardioprotective effect.

Potential of Calcitonin Gene-Related Peptide in Coronary Heart Disease

A subpopulation of capsaicin-sensitive cardiac C-fibre afferents co-store calcitonin gene-related peptide (CGRP), substance P and neurokinin A. CGRP exerts positive inotropic and chronotropic effects

Protection by capsaicin against attenuated endothelium-dependent vasorelaxation due to lysophosphatidylcholine

It is suggested that CGRP may be an endogenous vascular protective substance and prevent endothelial damage elicited by lysophosphatidylcholine in the rat aorta by means of systemic capsaicin treatment.

Arteriolar dilation mediated by capsaicin and calcitonin gene-related peptide in rats.

Results suggest that capsaicin can dilate microvessels by releasing CGRP, which can modulate tone, which is consistent with the hypothesis that this agent causes depletion of an endogenous vasodilator.

In vitro effects of capsaicin: antiarrhythmic and antiischemic activity.

The cardioprotection of calcitonin gene-related peptide-mediated preconditioning.