Nitric-Oxide Mediated Effects of Transdermal Capsaicin Patches on the Ischemic Threshold in Patients with Stable Coronary Disease

@article{Fragasso2004NitricOxideME,
  title={Nitric-Oxide Mediated Effects of Transdermal Capsaicin Patches on the Ischemic Threshold in Patients with Stable Coronary Disease},
  author={Gabriele Fragasso and Altin Palloshi and Pier Marco Piatti and Lucilla D. Monti and Enrico Rossetti and Emanuela Setola and Chiara Montano and Giorgio Bassanelli and G. Calori and Alberto Margonato},
  journal={Journal of Cardiovascular Pharmacology},
  year={2004},
  volume={44},
  pages={340-347}
}
Background Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release. However, no data exist on its effect following systemic administration in humans. Methods Twelve male patients with stable coronary disease and a persistently positive exercise were selected for study. According to a double blind, placebo-controlled, cross-over study, patients were randomized to placebo or 3 g oleic capsaicin-containing patches, on 2… 

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References

SHOWING 1-10 OF 34 REFERENCES

Effect of intravenous calcitonin gene related peptide on ischaemia threshold and coronary stenosis severity in humans.

Intravenous CGRP is a systemic arterial vasodilator which dilates coronary arteries at the site of atheromatous stenoses and delays the onset of myocardial ischaemia during treadmill exercise testing in patients with chronic stable angina.

Calcitonin gene-related peptide: a potent dilator of human epicardial coronary arteries.

Prior infusion of CGRP did not prevent coronary arterial spasm induced by ergonovine in two patients with variant angina, but a subsequent bolus of C GRP partially relieved the spasm.

Aggravation of myocardial infarction in the porcine heart by capsaicin-induced depletion of calcitonin gene-related peptide (CGRP).

This study indicates that peptides released from cardiac C fibers have a beneficial effect in myocardial ischemia and reperfusion and is a possible candidate for the mediation of the observed cardioprotective effect.

Potential of Calcitonin Gene-Related Peptide in Coronary Heart Disease

A subpopulation of capsaicin-sensitive cardiac C-fibre afferents co-store calcitonin gene-related peptide (CGRP), substance P and neurokinin A. CGRP exerts positive inotropic and chronotropic effects

Protection by capsaicin against attenuated endothelium-dependent vasorelaxation due to lysophosphatidylcholine

It is suggested that CGRP may be an endogenous vascular protective substance and prevent endothelial damage elicited by lysophosphatidylcholine in the rat aorta by means of systemic capsaicin treatment.

Arteriolar dilation mediated by capsaicin and calcitonin gene-related peptide in rats.

Results suggest that capsaicin can dilate microvessels by releasing CGRP, which can modulate tone, which is consistent with the hypothesis that this agent causes depletion of an endogenous vasodilator.

In vitro effects of capsaicin: antiarrhythmic and antiischemic activity.

The cardioprotection of calcitonin gene-related peptide-mediated preconditioning.