Nitric Oxide Links the Apical Na+ Transport to the Basolateral K+ Conductance in the Rat Cortical Collecting Duct

@article{Lu1997NitricOL,
  title={Nitric Oxide Links the Apical Na+ Transport to the Basolateral K+  Conductance in the Rat Cortical Collecting Duct },
  author={Ming Lu and Gerhard H. Giebisch and Wenhui Wang},
  journal={The Journal of General Physiology},
  year={1997},
  volume={110},
  pages={717 - 726}
}
We have used the patch clamp technique to study the effects of inhibiting the apical Na+ transport on the basolateral small-conductance K+ channel (SK) in cell-attached patches in cortical collecting duct (CCD) of the rat kidney. Application of 50 microM amiloride decreased the activity of SK, defined as nPo (a product of channel open probability and channel number), to 61% of the control value. Application of 1 microM benzamil, a specific Na+ channel blocker, mimicked the effects of amiloride… CONTINUE READING
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Regulation of the hyperpolarizationactivated K channel in the lateral membrane of the CCD

  • W. H. Wang
  • Am . J . Physiol .
  • 1995
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