Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse

@article{Steinert2008NitricOI,
  title={Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse},
  author={Joern R Steinert and Cornelia Kopp-Scheinpflug and Claire Baker and R. A. John Challiss and Raj Mistry and Martin D. Haustein and Sarah J. Griffin and Huaxia Tong and Bruce P. Graham and Ian D. Forsythe},
  journal={Neuron},
  year={2008},
  volume={60},
  pages={642-656}
}
Neuronal nitric oxide synthase (nNOS) is broadly expressed in the brain and associated with synaptic plasticity through NMDAR-mediated calcium influx. However, its physiological activation and the mechanisms by which nitric oxide (NO) influences synaptic transmission have proved elusive. Here, we exploit the unique input-specificity of the calyx of Held to characterize NO modulation at this glutamatergic synapse in the auditory pathway. NO is generated in an activity-dependent manner by MNTB… CONTINUE READING

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