• Corpus ID: 20383589

Nitrendipine-stimulated release of prostacyclin-like substance in normal and atherosclerotic animals.

  title={Nitrendipine-stimulated release of prostacyclin-like substance in normal and atherosclerotic animals.},
  author={Lilia Grodzińska and M Basista and Erik Ba{\vs}ista and Michelle Slawinski and J. Świȩs and Jerzy Stachura and R Ohlrogge},
  volume={37 4},
Nitrendipine (Bayotensin) is a dihydropyridine derivative that appears to preferentially dilate peripheral vessels by a cellular mechanism similar to those found with other calcium blocking agents. In this study nitrendipine when infused (0.2-0.3 mg/kg i.v.) into anaesthetized cats caused a release of a substance disaggregating platelet clumps which had adhered to blood superfused collagen strip. The appearance of this unstable disaggregating substance was prevented by the pretreatment of cats… 
Antithrombotic activity of nicardipine in spontaneously hypertensive rats.
The results suggest that the actions of nicardipine on calcium metabolism result in antithrombotic effect through an increased availability of vasodilating eicosanoids in vessel walls and through a reduced amount of prothromBotic agents (thromboxane, free fatty acids).
Inhibitory effect of clentiazem (TA-3090), a new calcium antagonist, on balloon catheter-induced intimal thickening of rabbit aorta
The results suggest that clentiazem exhibits an antiatherogenic effect, at least partly through prevention of smooth muscle cell proliferation in atheromatous lesions, in addition to its hypotensive action.
Calcium Antagonists Inhibit Elevated Potassium Efflux From Aorta of Aldosterone‐Salt Hypertensive Rats
The results suggest that the basal tension and elevated 42K efflux in aorta from aldosterone-salt hypertensive rats are supported by the entry of extracellular calcium into the tissue through potential-operated calcium channels.
Potential Biochemical Mechanisms of the Antiatherogenic Properties of Calcium Antagonists
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Effect of nifedipine on renal microvascular cholesterol accumulation and prostacyclin biosynthesis in cholesterol-fed rabbits.
It is suggested that calcium antagonists may have a beneficial effect in preventing the tissue cholesterol accumulation associated with a high-cholesterol diet and further suggest that these agents may have beneficial effects in the treatment of renal diseases associated with microvascular or glomerular lipid accumulation.
Concept of an antiatherosclerotic efficacy of calcium entry blockers
In two other studies on the inhibiting effect of dihydropyridine calcium entry blockers on the progression of coronary artery disease in man defining angiographic endpoints, the drugs were also shown to reduce the number of newly formed significant coronary lesions.
Management of Raynaud’s Phenomenon
Drugs active in the sympathetic control of vascular tone may well be best reserved for the most severe forms of Raynaud’s, especially perhaps those associated with tissue loss in the secondary disease.
Atherosklerose und Ca++-Kanalblocker
Unter Atherosklerose versteht man eine Gefaswanderkrankung, die sich durch funktionelle Veranderung des Endothels, die Infiltration mononuklearer Phagozyten, eine intimale Akkumulation von Lipiden
Calciumantagonisten bei organischen und funktionellen peripheren Durchblutungsstörungen
Im Folgenden werden Epidemiologie, Klinik, Diagnose und Pathophysiologie der PAVK, Thrombangiitis obliterans, Akrozyanose, des RaynaudPhanomens, Ergotismus, Blue-toe-Phanomens, von Frostbeulen und