Nitrative and oxidative DNA damage caused by K-ras mutation in mice.

Abstract

Ras mutation is important for carcinogenesis. Carcinogenesis consists of multi-step process with mutations in several genes. We investigated the role of DNA damage in carcinogenesis initiated by K-ras mutation, using conditional transgenic mice. Immunohistochemical analysis revealed that mutagenic 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8… (More)
DOI: 10.1016/j.bbrc.2011.08.076

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