Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases.

@article{Aoyama2000NitrationOM,
  title={Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases.},
  author={Koji Aoyama and Koichi Matsubara and Yasuhiro Fujikawa and Y Nagahiro and Kouichiro Shimizu and Nobuyuki Umegae and Nobuaki Hayase and Hiroyuki Shiono and Susumu Kobayashi},
  journal={Annals of neurology},
  year={2000},
  volume={47 4},
  pages={524-7}
}
Peroxynitrite can nitrate tyrosine residues of proteins. We examined nitrotyrosine-containing proteins in cerebrospinal fluid of 66 patients with neurogenic disease by immunoblot analysis. Nitrated tyrosine residue-containing protein was observed in the cerebrospinal fluid and was concluded to be manganese superoxide dismutase (Mn-SOD). The nitrated Mn-SOD level was strikingly elevated in amyotrophic lateral sclerosis patients and was slightly increased in Alzheimer's and Parkinson's disease… CONTINUE READING

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