Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets.

@article{Reynolds2009NitratedA,
  title={Nitrated \{alpha\}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets.},
  author={Ashley D. Reynolds and David K. Stone and R. Lee Mosley and Howard E. Gendelman},
  journal={Journal of immunology},
  year={2009},
  volume={182 7},
  pages={4137-49}
}
Microglial inflammatory neuroregulatory activities affect the tempo of nigrostriatal degeneration during Parkinson's disease (PD). Such activities are induced, in part, by misfolded, nitrated alpha-synuclein (N-alpha-syn) within Lewy bodies released from dying or dead dopaminergic neurons. Such pathobiological events initiate innate and adaptive immune responses affecting neurodegeneration. We posit that the neurobiological activities of activated microglia are affected by cell-protein and cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 73 extracted citations

Similar Papers

Loading similar papers…