Nitrate reductase assay for detection of drug resistance in Mycobacterium tuberculosis: simple and inexpensive method for low-resource laboratories.

@article{Lemus2006NitrateRA,
  title={Nitrate reductase assay for detection of drug resistance in Mycobacterium tuberculosis: simple and inexpensive method for low-resource laboratories.},
  author={Dihadenys Lemus and Ernesto Hilario Montoro and Miguel Echemend{\'i}a and Anandi Martin and Françoise Portaels and Juan Carlos Palomino},
  journal={Journal of medical microbiology},
  year={2006},
  volume={55 Pt 7},
  pages={861-3}
}
The nitrate reductase assay (NRA) was used as an alternative method for detection of resistance to the first-line antituberculous drugs isoniazid, rifampicin, ethambutol and streptomycin. A total of 320 strains of Mycobacterium tuberculosis were studied and the results compared with the proportion method (PM) on Löwenstein-Jensen medium. The mean time to obtain results was 10 days and the overall agreement between the NRA and PM was 98.8 %. The NRA was easy to perform and represents a useful… CONTINUE READING

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Comparative evaluation of the nitrate reduction assay, the MTT test, and the resazurin microtiter assay for drug susceptibility testing of clinical isolates of Mycobacterium tuberculosis

  • E. Montoro, D. Lemus, M. Echemendı́a, A. Martin, F. Portaels, J. C. Palomino
  • J Antimicrob Chemother
  • 2005
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