Nitrate-based vasodilators inhibit multiple vascular aldehyde dehydrogenases

  title={Nitrate-based vasodilators inhibit multiple vascular aldehyde dehydrogenases},
  author={Tonya C. Murphy and Roberta Arntzen and Matthew J. Picklo},
  journal={Cardiovascular Toxicology},
Nitrate-based vasodilators (NBVs) are commonly used to treat multiple sequelae of atherosclerosis. A commonly used NBV, glyceryl trinitrate (GTN) is bioactivated by mitochondrial, class 2 aldehyde dehydrogenase (ALDH2). ALDH2 and other ALDHs are NAD(P)+-dependent enzymes critical to the detoxification of cytotoxic lipid-aldehydes elevated in atherosclerotic lesions, such as trans-4-hydroxy-2-nonenal (HNE). The GTN bioactivation step, however, inactivates ALDH2 and may alter the metabolism of… CONTINUE READING
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