Nithiazide I. Chemical and Biological Studies on l-ethyl-3-(5-nitro-2-thiazolyl) urea and Related Compounds

@article{Cuckler1956NithiazideIC,
  title={Nithiazide I. Chemical and Biological Studies on l-ethyl-3-(5-nitro-2-thiazolyl) urea and Related Compounds},
  author={Ashton C. Cuckler and C M Malanga and Arthur J. Basso and R. C. O'neill and Karl Pfister},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1956},
  volume={92},
  pages={483 - 485}
}
Summary 1. The preparation of 1-mono-substituted and 1,1-disubstituted nitrothia-zolylureas has been described. 2. Antihisto-monad activity was demonstrated for mono-substituted thiazolylureas with not more than 4 carbon atoms. The 1-methyl compound was more toxic and less effective than the 1-ethyl derivative. The dimethyl compound was less toxic and also less effective than the mono-methyl compound. 3. In addition to therapeutic activity in enterohepatitis, nithi-azide [l-ethyl-3-(5-nitro-2… 
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ABSTRACT THE preceding papers in this series by Cuckler et al. (1956) and Cuckler and Malanga (1956) showed that nithiazide [1-ethyl-3-(5-nitro-2-thiazolyl) urea] was the most effective