Nithiazide 3 Tolerance studies in poultry

@article{Cuckler1957Nithiazide3T,
  title={Nithiazide 3 Tolerance studies in poultry},
  author={Ashton C. Cuckler and Curt C. Porter and Walther H. Ott},
  journal={Poultry Science},
  year={1957},
  volume={36},
  pages={529-536}
}
ABSTRACT THE preceding papers in this series by Cuckler et al. (1956) and Cuckler and Malanga (1956) showed that nithiazide [1-ethyl-3-(5-nitro-2-thiazolyl) urea] was the most effective antihistomonad (blackhead) agent in a series of closely related compounds. Furthermore, nithiazide was found more potent and less toxic than 2-amino-5-nitrothiazole in experimental enterohepatitis. This paper presents the results of studies on the absorption and excretion of nithiazide by turkeys and chickens… 
6 Citations

Evaluation of blackhead preventive drugs with regard to growth and feed efficiency of turkeys.

TLDR
Blackhead has been a problem to turkey producers for many years and is still considered one of the more important turkey diseases and many chemotherapeutic agents have been tested for the control of this disease.

The influence of several histomoniastats on performance of large white turkeys.

Abstract HISTOMONIASIS (blackhead disease or infectious enterohepatitis) continues to be one of the major disease problems in turkey production. The prevention and treatment of blackhead disease is

Histomonosis in poultry: previous and current strategies for prevention and therapy*

TLDR
Considering existing regulations and the overall outcome of experimental studies, it can be concluded that vaccination is very promising, despite the fact that various challenges need to be addressed until the first ever developed vaccine based upon live flagellates in human or bird medicine can be marketed.

Blackhead Disease (Histomoniasis) in Poultry: A Critical Review

TLDR
It was demonstrated that histomoniasis could spread rapidly through a flock of turkeys by direct contact, probably involving the phenomenon of cloacal drinking, and the lack of suitable treatment drugs or vaccines emphasizes the importance of prevention by worm control and management.

References

SHOWING 1-8 OF 8 REFERENCES

The Use of 2-Amino, 5-Nitrothiazole for the Induction of Moult in Yearling Hens

TLDR
A large number of poultrymen force-moult their yearling hens in an attempt to control the laying cycle, and the use of 2-amino, 5-nitrothiazole in the ration of turkey breeders caused a reduction in egg production.

Effect of 2-Acetamido-5-Nitrothiazole and 2-Amino-5-Nitrothiazole on Egg Production, Fertility, Hatchability, and Weight Gains in Turkeys

TLDR
Two studies were planned to determine the effect of both compounds, administered during the growing and/or breeding period, on reproductive performance and weight gains of normal turkeys that had not been exposed to enterohepatitis, using dosage schedules designed to approximate field use.

Nithiazide II. Effect on Enterohepatitis in Turkeys

  • A. C. CucklerC. Malanga
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1956
TLDR
Nithiazide was most effective when administered prior to infection or beginning 3 to 7 days after infection, and prevented mortality from enterohepatitis produced either by oral exposure to cecal worm eggs or by rectal inoculation of Histomonas meleagridis cultures.

Physiological Disturbance of the Reproductive System in White Leghorn Cockerels Following the Feeding of Enheptin

TLDR
The efficacy of Enheptin (2-amino, 5-nitrothiazole) in the treatment and prevention of blackhead (infectious enterohepatitis) of turkeys has been demonstrated and can be explained by assuming that the chickens were carriers of the blackhead.

Nithiazide I. Chemical and Biological Studies on l-ethyl-3-(5-nitro-2-thiazolyl) urea and Related Compounds

TLDR
In addition to therapeutic activity in enterohepatitis, nithi-azide [l-ethyl-3-(5-nitro-2-thiazolyl) urea] was found to have antitrichomonal activity but antimalarial, antitrypanosomal or anticoc-cidial activity was not demonstrable.

Duration of Sexual Retardation in S.C. White Leghorn Pullets and Cockerels Following Enheptin (2-Amino, 5-Nitrothiazole) Feeding

TLDR
The work of Grumbles, Boney and Turk (1952) indicated a reduction in egg production, fertility and hatchability of turkey hens fed a diet containing 0.1% 2-amino, 5-nitrothiazole.

Effect of 2-Acetamido-5-Nitrothiazole on Egg Production, Fertility, Hatchability, and Weight Gains in Chickens

TLDR
Robblee and Clandinin (1954) found that the drug induced moult in hens that had reached the end of their first laying year when fed at a level of 0.1 percent for a suitable period of time.