Nitazoxanide: a new broad spectrum antiparasitic agent

@article{WhiteJr2004NitazoxanideAN,
  title={Nitazoxanide: a new broad spectrum antiparasitic agent},
  author={A. Clinton White Jr.},
  journal={Expert Review of Anti-infective Therapy},
  year={2004},
  volume={2},
  pages={43 - 49}
}
  • A. C. White Jr.
  • Published 1 February 2004
  • Medicine, Biology
  • Expert Review of Anti-infective Therapy
Nitazoxanide (Alinia®, Romark Laboratories) was synthesized based on the structure of niclosamide. In vitro studies have demonstrated activity against a broad range of parasites as well as some bacteria. Three controlled trials demonstrated efficacy in cryptosporidiosis, however, the efficacy in advanced AIDS patients (CD4 cell counts = 50) at approved doses was limited. Trials have also demonstrated efficacy comparable to metronidazole (Flagyl®, GD Searle and Co.) in giardiasis with fewer side… 
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References

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Nitazoxanide: an important advance in anti-parasitic therapy.
  • A. White
  • Medicine
    The American journal of tropical medicine and hygiene
  • 2003
TLDR
The development of nitazoxanide was originally discovered in the 1980s by Jean Francois Rossignol at the Pasteur Institute and focused on development of the drug for treatment of cryptosporidiosis in acquired immunodeficiency syndrome.
Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana infections.
TLDR
Nitazoxanide, a nitrothiazole derivative, was tested in patients infected with Taenia saginata and 18 infected with Hymenolepis nana and tolerance of the drug was good at both dose levels used.
Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico.
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TLDR
Patients with malabsorption and cholangitis due to Coccidia such as Isospora belli and Cryptosporidium spp.
In Vitro Parasiticidal Effect of Nitazoxanide against Echinococcus multilocularis Metacestodes
TLDR
The in vitro parasiticidal effect of nitazoxanide (NTZ), a broad-spectrum drug used against intestinal parasites and bacteria, was investigated and showed that in vitro treatment of E. multilocularis metacestodes with NTZ induced high levels of alkaline phosphatase activity in the medium.
Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model.
TLDR
Nitazoxanide (NTZ) was compared for curative activity with sinefungin (SNF) and paromomycin (PRM) in immunosuppressed rats, a screening model for anticryptosporidial agents and shedding inhibition was unchanged in NTZ-treated rats.
Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico.
TLDR
Nitazoxanide was very well tolerated, with no serious adverse effects reported, in the treatment of mixed parasite infections with both intestinal protozoa and helminths in children.
The efficacy and tolerability of triclabendazole in Cuban patients with latent and chronic Fasciola hepatica infection.
TLDR
Triclabendazole 20 mg/kg is an effective therapy for the treatment of F. hepatica infection in patients who have failed to respond to other antihelminthic agents.
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