Nitazoxanide: a new broad spectrum antiparasitic agent.

@article{White2004NitazoxanideAN,
  title={Nitazoxanide: a new broad spectrum antiparasitic agent.},
  author={Clinton A White},
  journal={Expert review of anti-infective therapy},
  year={2004},
  volume={2 1},
  pages={43-9}
}
Nitazoxanide (Alinia, Romark Laboratories) was synthesized based on the structure of niclosamide. In vitro studies have demonstrated activity against a broad range of parasites as well as some bacteria. Three controlled trials demonstrated efficacy in cryptosporidiosis, however, the efficacy in advanced AIDS patients (CD4 cell counts = 50) at approved doses was limited. Trials have also demonstrated efficacy comparable to metronidazole (Flagyl, GD Searle and Co.) in giardiasis with fewer side… CONTINUE READING

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