Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections

@article{Hemphill2006NitazoxanideAB,
  title={Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections},
  author={A. Hemphill and Joachim Mueller and M. Esposito},
  journal={Expert Opinion on Pharmacotherapy},
  year={2006},
  volume={7},
  pages={953 - 964}
}
Colonisation of the gastrointestinal tract by anaerobic bacteria, protozoa, trematodes, cestodes and/or nematodes and other infectious pathogens, including viruses, represents a major cause of morbidity and mortality in Africa, South America and southeast Asia, as well as other parts of the world. Nitazoxanide is a member of the thiazolide class of drugs with a documented broad spectrum of activity against parasites and anaerobic bacteria. Moreover, the drug has recently been reported to have a… Expand
View on Taylor & Francis
ncbi.nlm.nih.gov
128 Citations
Highly Influential Citations
4
Background Citations
58
Methods Citations
3
Results Citations
5

128 Citations

Citation Type

Citation Type

Thiazolides, a Novel Class of Anti-Infective Drugs, Effective Against Viruses, Bacteria, Intracellular and Extracellular Protozoan Parasites and Proliferating Mammalian Cells
TLDR
Biochemical and genetic approaches have allowed the identification of respective targets and the molecular basis of resistance formation, and studies strongly suggest that NTZ and other thiazolides exhibit multiple mechanisms of action. Expand
Novel amidines and analogues as promising agents against intracellular parasites: a systematic review
TLDR
This review summarizes the knowledge on amidines and analogues with respect to their synthesis, pharmacological profile, mechanistic and biological effects upon a range of intracellular protozoan parasites to contribute to the future design and structure optimization of new aromatic dicationic compounds as novel antiparasitic drug candidates. Expand
Nitazoxanide: nematicidal mode of action and drug combination studies.
TLDR
It is found that NTZ combines synergistically with other classes of anthelmintic drugs, i.e. albendazole and pyrantel, making it a good candidate for further studies on its use in drug combination therapy of STH infections and validate avr-14 as an excellent target for pan-STH therapy. Expand
Current treatment options for Dientamoeba fragilis infections.
TLDR
There is very little in vitro susceptibility data available for the organism making some current treatment options questionable, and all treatment options currently available for dientamoebiasis are critically discussed. Expand
Evaluation of Putative Anti-cryptosporidial Drugs in an in vitro Culture System
TLDR
Testing a substituted benzimidazole and a heterocyclic substituted 1,2,4-triazin, both drugs with known anti-protozoal activity, for their potential ability to interfere with Cryptosporidium parvum development in vitro found both BAY-AB24992 and Bay-AF76184 should be considered for further evaluation. Expand
In vitro and in vivo antileishmanial efficacy of nitazoxanide against Leishmania donovani
TLDR
Results indicated NTZ may be a novel therapeutic drug for leishmaniasis, indicating that NTZ can affect the ultrastructure of parasite promastigote and efficiently inhibit the parasite growth. Expand
Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review
TLDR
Current clinical treatment strategies and agents under clinical development for C. difficile infection are summarized and newly reported anti-difficile agents that have been evaluated or reevaluated in the last five years are reviewed. Expand
Send Orders for Reprints to Reprints@benthamscience.net Progress in the Discovery of Treatments for C. Difficile Infection: a Clini- Cal and Medicinal Chemistry Review
    A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19
    TLDR
    Nitazoxanide a US-FDA approved antiprotozoal drug is presented, as one such promising candidate with potential for repurposing in COVID-19, which has the potential to boost host innate immune responses and thereby tackle the life-threatening cytokine storm. Expand
    Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs.
    TLDR
    The thiazolide nitazoxanide (NTZ) and some derivatives exhibit considerable in vitro activities against a broad range of parasites, including the apicomplexans Neospora caninum and Toxoplasma gondii tachyzoites, and inhibited recQR activity on menadione in a concentration-dependent manner. Expand
    ...
    1
    2
    3
    4
    5
    ...

    References

    SHOWING 1-10 OF 70 REFERENCES
    Nitazoxanide, a Nitrothiazolide Antiparasitic Drug, Is an Anti-Helicobacter pylori Agent with Anti-Vacuolating Toxin Activity
    TLDR
    It was apparent that both NTZ and TIZ are highly effective against H. pylori, even when the bacteria are resistant to MTZ. Expand
    Mechanisms of action of nitazoxanide and related drugs against helminths.
    TLDR
    The 5-nitrothiazole, nitazoxanide, is a novel compound with a broad spectrum of activity that is effective against anaerobic/microaerophilic environments, but also likely to affect helminths by a direct effect on neurotransmission and protonophoric uncoupling. Expand
    Nitazoxanide: a new broad spectrum antiparasitic agent.
    • C. White
    • Biology, Medicine
    • Expert review of anti-infective therapy
    • 2004
    TLDR
    Nitazoxanide is the first agent proven to be effective in cryptosporidiosis and has also proven efficacy in giardiasis, and is efficacious again intestinal helminths. Expand
    Nitazoxanide: a new thiazolide antiparasitic agent.
    • L. Fox, L. Saravolatz
    • Medicine
    • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
    • 2005
    TLDR
    Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths and is well tolerated, with primarily mild gastrointestinal side effects. Expand
    Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico.
    TLDR
    Treatment with nitazoxanide was 71-100% effective in eliminating evidence of infection with Entamoeba histolytica/E. Expand
    In Vitro Parasiticidal Effect of Nitazoxanide against Echinococcus multilocularis Metacestodes
    TLDR
    The in vitro parasiticidal effect of nitazoxanide (NTZ), a broad-spectrum drug used against intestinal parasites and bacteria, was investigated and showed that in vitro treatment of E. multilocularis metacestodes with NTZ induced high levels of alkaline phosphatase activity in the medium. Expand
    Treatment of intestinal parasitic infections: a review of nitazoxanide.
    TLDR
    Nitazoxanide, a pyruvate ferredoxin oxidoreductase inhibitor, is a new antiparasitic drug notable for its activity in treating protozoan infections, including Cryptosporidium, which cause persistent diarrhoea and malnutrition in children throughout the developing world. Expand
    In Vitro Efficacies of Nitazoxanide and Other Thiazolides against Neospora caninum Tachyzoites Reveal Antiparasitic Activity Independent of the Nitro Group
    TLDR
    It is shown that the thiazole-associated nitro group is not necessarily required for the action of the drug and that methylation of the salicylate ring can result in complete abrogation ofThe antiparasitic activity of NTZ, depending on the positioning of the methyl group. Expand
    In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes.
    TLDR
    In vitro efficacy of nitazoxanide, a broad-spectrum drug used against intestinal parasites and bacteria, was investigated and indicates a potential for nitaz oxanide as an alternative treatment option against CE. Expand
    In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
    TLDR
    Under aerobic conditions, nitazoxanide demonstrated poor activity against members of the family Enterobacteriacae and Pseudomonas, Staphylococcus, and Enterococcus species, and the same results were obtained when culture was performed under anaerobic conditions with the notable exception of the results against Staphlyococcus aureus. Expand
    ...
    1
    2
    3
    4
    5
    ...