Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections

@article{Hemphill2006NitazoxanideAB,
  title={Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections},
  author={Andrew Hemphill and Joachim Mueller and Marco Esposito},
  journal={Expert Opinion on Pharmacotherapy},
  year={2006},
  volume={7},
  pages={953 - 964}
}
Colonisation of the gastrointestinal tract by anaerobic bacteria, protozoa, trematodes, cestodes and/or nematodes and other infectious pathogens, including viruses, represents a major cause of morbidity and mortality in Africa, South America and southeast Asia, as well as other parts of the world. Nitazoxanide is a member of the thiazolide class of drugs with a documented broad spectrum of activity against parasites and anaerobic bacteria. Moreover, the drug has recently been reported to have a… 
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134 Citations
Highly Influential Citations
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134 Citations

Thiazolides, a Novel Class of Anti-Infective Drugs, Effective Against Viruses, Bacteria, Intracellular and Extracellular Protozoan Parasites and Proliferating Mammalian Cells
TLDR
Biochemical and genetic approaches have allowed the identification of respective targets and the molecular basis of resistance formation, and studies strongly suggest that NTZ and other thiazolides exhibit multiple mechanisms of action.
Novel amidines and analogues as promising agents against intracellular parasites: a systematic review
TLDR
This review summarizes the knowledge on amidines and analogues with respect to their synthesis, pharmacological profile, mechanistic and biological effects upon a range of intracellular protozoan parasites to contribute to the future design and structure optimization of new aromatic dicationic compounds as novel antiparasitic drug candidates.
Nitazoxanide: nematicidal mode of action and drug combination studies.
Current treatment options for Dientamoeba fragilis infections.
Evaluation of Putative Anti-cryptosporidial Drugs in an in vitro Culture System
TLDR
Testing a substituted benzimidazole and a heterocyclic substituted 1,2,4-triazin, both drugs with known anti-protozoal activity, for their potential ability to interfere with Cryptosporidium parvum development in vitro found both BAY-AB24992 and Bay-AF76184 should be considered for further evaluation.
In vitro and in vivo antileishmanial efficacy of nitazoxanide against Leishmania donovani
TLDR
Results indicated NTZ may be a novel therapeutic drug for leishmaniasis, indicating that NTZ can affect the ultrastructure of parasite promastigote and efficiently inhibit the parasite growth.
Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review
TLDR
Current clinical treatment strategies and agents under clinical development for C. difficile infection are summarized and newly reported anti-difficile agents that have been evaluated or reevaluated in the last five years are reviewed.
A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19
Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs.
Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model
TLDR
Results suggest that gut repopulation with beneficial (non-PFOR) bacteria, considered essential for protection against CDI, rebounds much sooner with amixicile therapy than with vancomycin or fidaxomicin, and appears to be a very promising new candidate for treatment of CDI.
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References

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TLDR
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TLDR
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TLDR
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