Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections

@article{Hemphill2006NitazoxanideAB,
  title={Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections},
  author={A. Hemphill and Joachim Mueller and M. Esposito},
  journal={Expert Opinion on Pharmacotherapy},
  year={2006},
  volume={7},
  pages={953 - 964}
}
Colonisation of the gastrointestinal tract by anaerobic bacteria, protozoa, trematodes, cestodes and/or nematodes and other infectious pathogens, including viruses, represents a major cause of morbidity and mortality in Africa, South America and southeast Asia, as well as other parts of the world. Nitazoxanide is a member of the thiazolide class of drugs with a documented broad spectrum of activity against parasites and anaerobic bacteria. Moreover, the drug has recently been reported to have a… Expand
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References

SHOWING 1-10 OF 70 REFERENCES
Nitazoxanide, a Nitrothiazolide Antiparasitic Drug, Is an Anti-Helicobacter pylori Agent with Anti-Vacuolating Toxin Activity
TLDR
It was apparent that both NTZ and TIZ are highly effective against H. pylori, even when the bacteria are resistant to MTZ. Expand
Mechanisms of action of nitazoxanide and related drugs against helminths.
TLDR
The 5-nitrothiazole, nitazoxanide, is a novel compound with a broad spectrum of activity that is effective against anaerobic/microaerophilic environments, but also likely to affect helminths by a direct effect on neurotransmission and protonophoric uncoupling. Expand
Nitazoxanide: a new broad spectrum antiparasitic agent.
  • C. White
  • Biology, Medicine
  • Expert review of anti-infective therapy
  • 2004
TLDR
Nitazoxanide is the first agent proven to be effective in cryptosporidiosis and has also proven efficacy in giardiasis, and is efficacious again intestinal helminths. Expand
Nitazoxanide: a new thiazolide antiparasitic agent.
  • L. Fox, L. Saravolatz
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
TLDR
Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths and is well tolerated, with primarily mild gastrointestinal side effects. Expand
Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico.
TLDR
Treatment with nitazoxanide was 71-100% effective in eliminating evidence of infection with Entamoeba histolytica/E. Expand
In Vitro Parasiticidal Effect of Nitazoxanide against Echinococcus multilocularis Metacestodes
TLDR
The in vitro parasiticidal effect of nitazoxanide (NTZ), a broad-spectrum drug used against intestinal parasites and bacteria, was investigated and showed that in vitro treatment of E. multilocularis metacestodes with NTZ induced high levels of alkaline phosphatase activity in the medium. Expand
Treatment of intestinal parasitic infections: a review of nitazoxanide.
TLDR
Nitazoxanide, a pyruvate ferredoxin oxidoreductase inhibitor, is a new antiparasitic drug notable for its activity in treating protozoan infections, including Cryptosporidium, which cause persistent diarrhoea and malnutrition in children throughout the developing world. Expand
In Vitro Efficacies of Nitazoxanide and Other Thiazolides against Neospora caninum Tachyzoites Reveal Antiparasitic Activity Independent of the Nitro Group
TLDR
It is shown that the thiazole-associated nitro group is not necessarily required for the action of the drug and that methylation of the salicylate ring can result in complete abrogation ofThe antiparasitic activity of NTZ, depending on the positioning of the methyl group. Expand
In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes.
TLDR
In vitro efficacy of nitazoxanide, a broad-spectrum drug used against intestinal parasites and bacteria, was investigated and indicates a potential for nitaz oxanide as an alternative treatment option against CE. Expand
In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
TLDR
Under aerobic conditions, nitazoxanide demonstrated poor activity against members of the family Enterobacteriacae and Pseudomonas, Staphylococcus, and Enterococcus species, and the same results were obtained when culture was performed under anaerobic conditions with the notable exception of the results against Staphlyococcus aureus. Expand
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