Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections
@article{Hemphill2006NitazoxanideAB, title={Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections}, author={Andrew Hemphill and Joachim Mueller and Marco Esposito}, journal={Expert Opinion on Pharmacotherapy}, year={2006}, volume={7}, pages={953 - 964} }
Colonisation of the gastrointestinal tract by anaerobic bacteria, protozoa, trematodes, cestodes and/or nematodes and other infectious pathogens, including viruses, represents a major cause of morbidity and mortality in Africa, South America and southeast Asia, as well as other parts of the world. Nitazoxanide is a member of the thiazolide class of drugs with a documented broad spectrum of activity against parasites and anaerobic bacteria. Moreover, the drug has recently been reported to have a…
134 Citations
Thiazolides, a Novel Class of Anti-Infective Drugs, Effective Against Viruses, Bacteria, Intracellular and Extracellular Protozoan Parasites and Proliferating Mammalian Cells
- Biology, Chemistry
- 2012
Biochemical and genetic approaches have allowed the identification of respective targets and the molecular basis of resistance formation, and studies strongly suggest that NTZ and other thiazolides exhibit multiple mechanisms of action.
Novel amidines and analogues as promising agents against intracellular parasites: a systematic review
- BiologyParasitology
- 2013
This review summarizes the knowledge on amidines and analogues with respect to their synthesis, pharmacological profile, mechanistic and biological effects upon a range of intracellular protozoan parasites to contribute to the future design and structure optimization of new aromatic dicationic compounds as novel antiparasitic drug candidates.
Nitazoxanide: nematicidal mode of action and drug combination studies.
- BiologyMolecular and biochemical parasitology
- 2014
Current treatment options for Dientamoeba fragilis infections.
- Medicine, BiologyInternational journal for parasitology. Drugs and drug resistance
- 2012
Evaluation of Putative Anti-cryptosporidial Drugs in an in vitro Culture System
- Biology, MedicineParasitology Research
- 2013
Testing a substituted benzimidazole and a heterocyclic substituted 1,2,4-triazin, both drugs with known anti-protozoal activity, for their potential ability to interfere with Cryptosporidium parvum development in vitro found both BAY-AB24992 and Bay-AF76184 should be considered for further evaluation.
In vitro and in vivo antileishmanial efficacy of nitazoxanide against Leishmania donovani
- Biology, MedicineParasitology Research
- 2010
Results indicated NTZ may be a novel therapeutic drug for leishmaniasis, indicating that NTZ can affect the ultrastructure of parasite promastigote and efficiently inhibit the parasite growth.
Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review
- Medicine, BiologyCurrent topics in medicinal chemistry
- 2014
Current clinical treatment strategies and agents under clinical development for C. difficile infection are summarized and newly reported anti-difficile agents that have been evaluated or reevaluated in the last five years are reviewed.
A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19
- BiologyEuropean Journal of Pharmacology
- 2020
Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs.
- BiologyExperimental parasitology
- 2011
Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 2012
Results suggest that gut repopulation with beneficial (non-PFOR) bacteria, considered essential for protection against CDI, rebounds much sooner with amixicile therapy than with vancomycin or fidaxomicin, and appears to be a very promising new candidate for treatment of CDI.
References
SHOWING 1-10 OF 70 REFERENCES
Nitazoxanide, a Nitrothiazolide Antiparasitic Drug, Is an Anti-Helicobacter pylori Agent with Anti-Vacuolating Toxin Activity
- BiologyChemotherapy
- 1999
It was apparent that both NTZ and TIZ are highly effective against H. pylori, even when the bacteria are resistant to MTZ.
Mechanisms of action of nitazoxanide and related drugs against helminths.
- Biology
- 2004
The 5-nitrothiazole, nitazoxanide, is a novel compound with a broad spectrum of activity that is effective against anaerobic/microaerophilic environments, but also likely to affect helminths by a direct effect on neurotransmission and protonophoric uncoupling.
Nitazoxanide: a new broad spectrum antiparasitic agent.
- Medicine, BiologyExpert review of anti-infective therapy
- 2004
Nitazoxanide is the first agent proven to be effective in cryptosporidiosis and has also proven efficacy in giardiasis, and is efficacious again intestinal helminths.
Nitazoxanide: a new thiazolide antiparasitic agent.
- Medicine, BiologyClinical infectious diseases : an official publication of the Infectious Diseases Society of America
- 2005
Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths and is well tolerated, with primarily mild gastrointestinal side effects.
Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico.
- Biology, MedicineTransactions of the Royal Society of Tropical Medicine and Hygiene
- 1997
In Vitro Parasiticidal Effect of Nitazoxanide against Echinococcus multilocularis Metacestodes
- BiologyAntimicrobial Agents and Chemotherapy
- 2003
The in vitro parasiticidal effect of nitazoxanide (NTZ), a broad-spectrum drug used against intestinal parasites and bacteria, was investigated and showed that in vitro treatment of E. multilocularis metacestodes with NTZ induced high levels of alkaline phosphatase activity in the medium.
Treatment of intestinal parasitic infections: a review of nitazoxanide.
- Medicine, BiologyTrends in parasitology
- 2002
In Vitro Efficacies of Nitazoxanide and Other Thiazolides against Neospora caninum Tachyzoites Reveal Antiparasitic Activity Independent of the Nitro Group
- BiologyAntimicrobial Agents and Chemotherapy
- 2005
It is shown that the thiazole-associated nitro group is not necessarily required for the action of the drug and that methylation of the salicylate ring can result in complete abrogation ofThe antiparasitic activity of NTZ, depending on the positioning of the methyl group.
In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes.
- Biology, MedicineThe Journal of antimicrobial chemotherapy
- 2004
In vitro efficacy of nitazoxanide, a broad-spectrum drug used against intestinal parasites and bacteria, was investigated and indicates a potential for nitaz oxanide as an alternative treatment option against CE.
In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
- Biology, MedicineAntimicrobial agents and chemotherapy
- 1996
Under aerobic conditions, nitazoxanide demonstrated poor activity against members of the family Enterobacteriacae and Pseudomonas, Staphylococcus, and Enterococcus species, and the same results were obtained when culture was performed under anaerobic conditions with the notable exception of the results against Staphlyococcus aureus.