NirN protein from Pseudomonas aeruginosa is a novel electron-bifurcating dehydrogenase catalyzing the last step of heme d1 biosynthesis.

@article{Adamczack2014NirNPF,
  title={NirN protein from Pseudomonas aeruginosa is a novel electron-bifurcating dehydrogenase catalyzing the last step of heme d1 biosynthesis.},
  author={Julia Adamczack and Martin Hoffmann and Ulrich Papke and Kristin Haufschildt and Tristan Nicke and Martin Br{\"o}ring and Murat Sezer and Rebecca Weimar and Uwe Kuhlmann and Peter Hildebrandt and Gunhild Layer},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 44},
  pages={30753-62}
}
Heme d1 plays an important role in denitrification as the essential cofactor of the cytochrome cd1 nitrite reductase NirS. At present, the biosynthesis of heme d1 is only partially understood. The last step of heme d1 biosynthesis requires a so far unknown enzyme that catalyzes the introduction of a double bond into one of the propionate side chains of the tetrapyrrole yielding the corresponding acrylate side chain. In this study, we show that a Pseudomonas aeruginosa PAO1 strain lacking the… CONTINUE READING
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