Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development.

@article{Gause2006NippedATT,
  title={Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development.},
  author={Maria Gause and Joel C. Eissenberg and Amy F Macrae and M Janelle Odom Dorsett and Ziva Misulovin and Dale Dorsett},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 6},
  pages={2347-59}
}
The Notch receptor controls development by activating transcription of specific target genes in response to extracellular signals. The factors that control assembly of the Notch activator complex on target genes and its ability to activate transcription are not fully known. Here we show, through genetic and molecular analysis, that the Drosophila Nipped-A protein is required for activity of Notch and its coactivator protein, mastermind, during wing development. Nipped-A and mastermind also… CONTINUE READING