Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice.

@article{Egashira2003NinjinyoeitoA,
  title={Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice.},
  author={Naoto Egashira and Mitsutoshi Yuzurihara and Naoko Hattori and Iwao Sakakibara and Atsushi Ishige},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2003},
  volume={10 6-7},
  pages={467-73}
}
We investigated the effect of Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang), a Japanese herbal medicine, and found that 1000 mg/kg p.o. improved the scopolamine-induced impairment of passive avoidance response in mice. Further, the same dose of Ninjin-yoei-to enhanced oxotremorine-induced tremors in mice. The water extract of Polygalae radix, one of the constituent herbs of Ninjin-yoei-to, at a dose of 100 mg/kg significantly improved the scopolamine-induced impairment of passive avoidance response… CONTINUE READING

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