Nineteenth century research on naturally occurring cell death and related phenomena

  title={Nineteenth century research on naturally occurring cell death and related phenomena},
  author={Peter G. H. Clarke and Stephanie Clarke},
  journal={Anatomy and Embryology},
Research on naturally occurring cell death is older than current opinion gives credit. More than 100 nineteenth century publications deal with it, and we review most of these. Soon after the establishment of the cell theory by Schleiden and Schwann, Carl Vogt (1842) reported cell death in the notochord and adjacent cartilage of metamorphic toads. Subsequent landmark discoveries included the massive cell death that occurs in pupating diptera (Weismann 1864), chondrocyte death during endochondral… CONTINUE READING


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