Ninein is expressed in the cytoplasm of angiogenic tip-cells and regulates tubular morphogenesis of endothelial cells.

@article{Matsumoto2008NineinIE,
  title={Ninein is expressed in the cytoplasm of angiogenic tip-cells and regulates tubular morphogenesis of endothelial cells.},
  author={Taro Matsumoto and Petter Schiller and Lothar C. Dieterich and Fuad Bahram and Yuji Iribe and Ulf Hellman and Charlotte Wikner and Gordon Chan and Lena Claesson-Welsh and Anna I Dimberg},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 12},
  pages={2123-30}
}
OBJECTIVE Angiogenesis is an integral part of many physiological processes but may also aggravate pathological conditions such as cancer. Development of effective angiogenesis inhibitors requires a thorough understanding of the molecular mechanisms regulating vessel formation. The aim of this project was to identify proteins that regulate tubular morphogenesis of endothelial cells. METHODS AND RESULTS Phosphotyrosine-dependent affinity-purification and mass spectrometry showed tyrosine… CONTINUE READING