Nine steps to proteomic wisdom: A practical guide to using protein-protein interaction networks and molecular pathways as a framework for interpreting disease proteomic profiles.

Abstract

A major aim of proteomic profiling of disease is to uncover the mechanistic basis of a given pathology. High-throughput experimental techniques continue to advance rapidly, but are still plagued by high rates of false negatives, false positives, and other spurious findings. By reducing a disease profile to a subset of differentially expressed proteins and… (More)
DOI: 10.1002/prca.200700146

Topics

4 Figures and Tables

Cite this paper

@article{Isserlin2007NineST, title={Nine steps to proteomic wisdom: A practical guide to using protein-protein interaction networks and molecular pathways as a framework for interpreting disease proteomic profiles.}, author={Ruth Isserlin and Andrew Emili}, journal={Proteomics. Clinical applications}, year={2007}, volume={1 9}, pages={1156-68} }