Nimodipine nanocrystals for oral bioavailability improvement: role of mesenteric lymph transport in the oral absorption.

@article{Fu2013NimodipineNF,
  title={Nimodipine nanocrystals for oral bioavailability improvement: role of mesenteric lymph transport in the oral absorption.},
  author={Qiang Fu and Jin Sun and Xiaoyu Ai and Peng Zhang and Mo Li and Yongjun Wang and Xiaohong Liu and Yinghua Sun and Xiaofan Sui and Le Sun and Xiaopeng Han and Meng Zhu and Yuyang Zhang and Siling Wang and Zhonggui He},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={448 1},
  pages={290-7}
}
PURPOSE We had conducted a comprehensive study on preparation, characterization and pharmacokinetics of nimodipine nanocrystals for oral administration previously, and nimodipine nanocrystals displayed lower dissolution profiles but higher bioavailability than Nimotop(®). In this study, we aimed at elucidating the reasons of unfavorable in vitro in vivo correlation for NMD nanocrystals and Nimotop(®) with a hypothesis that special oral absorption mechanism was involved in the absorption of… CONTINUE READING

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