Nimodipine nanocrystals for oral bioavailability improvement: preparation, characterization and pharmacokinetic studies.

@article{Fu2013NimodipineNF,
  title={Nimodipine nanocrystals for oral bioavailability improvement: preparation, characterization and pharmacokinetic studies.},
  author={Qiang Fu and Jin Sun and Dong Zhang and Mo Li and Yongjun Wang and Guixia Ling and Xiaohong Liu and Yinghua Sun and Xiaofan Sui and Cong Luo and Le Sun and Xiaopeng Han and He Lian and Meng Zhu and Siling Wang and Zhonggui He},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2013},
  volume={109},
  pages={161-6}
}
This study intended to develop nimodipine (NMD) nanocrystals with different sizes for oral administration and to investigate the relationship between dissolution and pharmacokinetics for NMD nanocrystals and Nimotop(®). NMD nanocrystals were prepared by combination of microprecipitation and high pressure homogenization and were further lyophilized. The particle size, morphology and aqueous solubility of the NMD nanocrystals were determined. With Nimotop(®) as the control, the dissolution rate… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
15 Citations
11 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 11 references

Dissolution media simulating fasted and fed states

  • M. Marques
  • Dissolution Technologies,
  • 2004
1 Excerpt

Similar Papers

Loading similar papers…