Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study

@article{Santilln1998NimodipineenhancedOA,
  title={Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study},
  author={R. Santill{\'a}n and M. A. Hurl{\'e} and J. Armijo and R. D. L. Mozos and J. Fl{\'o}rez},
  journal={Pain},
  year={1998},
  volume={76},
  pages={17-26}
}
  • R. Santillán, M. A. Hurlé, +2 authors J. Flórez
  • Published 1998
  • Medicine
  • Pain
  • &NA; The ability of nimodipine, a dihydropyridine calcium antagonist, to reduce the daily dose of oral morphine in cancer patients who had developed dose escalation, was tested in 54 patients under randomized, double‐blind, placebo‐controlled conditions. We selected patients that required at least two successive increments of morphine to maintain pain relief. A possible pharmacokinetic interaction between nimodipine and morphine was also studied in 14 patients by assaying steady‐state serum… CONTINUE READING

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