Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study
@article{Santilln1998NimodipineenhancedOA, title={Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study}, author={Rosa Santill{\'a}n and Mar{\'i}a A. Hurl{\'e} and Juan A. Armijo and Rosario de los Mozos and Jes{\'u}s Fl{\'o}rez}, journal={Pain}, year={1998}, volume={76}, pages={17-26} }
51 Citations
Perioperative Nimodipine and Postoperative Analgesia
- MedicineAnesthesia and analgesia
- 2006
It is demonstrated that increased morphine consumption after 12 h in postoperative patients receiving nimodipine is demonstrated, suggesting that, in patients undergoing knee replacement surgery, it has no adjunctive analgesic effect and may actually inhibit the analgesicEffect of morphine.
A Comparative Study with Oral Nifedipine, Intravenous Nimodipine, and Magnesium Sulfate in Postoperative Analgesia
- Medicine, BiologyAnesthesia and analgesia
- 2000
In conclusion, the perioperative application of oral nifedipine, IV nimodIPine, or IV magnesium sulfate failed to decrease postoperative morphine requirements after colorectal surgery.
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers
- Medicine, BiologyAnesthesia and analgesia
- 2000
Both a pharmacodynamic and pharmacokinetic interaction between morphine and GBP is revealed, leading to an increased analgesic effect of morphine + GBP, and the well tolerated combination of gabapentin and morphine may improve pain therapy.
Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain.
- MedicinePain medicine
- 2008
Ziconotide, combined with stable intrathecal morphine, may reduce pain and decrease systemic opioid use in patients with pain inadequately controlled by intratheCal morphine alone.
Enhanced analgesic effect of morphine-nimodipine combination after intraspinal administration as compared to systemic administration in mice
- Biology, MedicineJournal of Biosciences
- 2007
Addition of nimodipine to morphine potentiated the analgesic response of the latter when administer through the intraspinal route but not when administered through systemic route, which may be due to direct inhibitory effect of morphine and nimmodipine on neurons of superficial laminae of the spinal cord after binding to Μ-opioid receptors and L-type calcium channels respectively.
Nimodipine is more effective than nifedipine in attenuating morphine tolerance on chronic co-administration in the rat tail-flick test.
- Biology, MedicineIndian journal of experimental biology
- 2008
It is shown for the first time that nimodipine is more effective than nifedipine and that these L-CCBs continue to be effective, even 12 hr after administration in the tail-flick test.
Morphine in cancer pain management: a practical guide
- Biology, MedicineSupportive Care in Cancer
- 2002
Abstract. Morphine is the most practical and versatile analgesic for the relief of severe pain associated with advanced cancer. Information is available in the literature about its use in routine…
Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys.
- Biology, MedicineEuropean journal of pharmacology
- 2000
Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
- Medicine, PsychologyExperimental and clinical psychopharmacology
- 2013
Gabapentin reduces opioid use during a 10-day buprenorphine detoxification procedure, and urine results showed a Drug × Time interaction, such that the probability of opioid-positive urines significantly decreased over time in the gabap Quentin versus placebo groups during Weeks 3 and 4.
Adjuncts to opioid therapy
- MedicineThe Journal of the American Osteopathic Association
- 2002
Inadequate analgesia can become a suicidogen, ie, any factor that causes a patient to want to commit suicide, when patients are likely to request physicians to provide some method to accelerate their death.
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