Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study

  title={Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study},
  author={Rosa Santill{\'a}n and Mar{\'i}a A. Hurl{\'e} and Juan A. Armijo and Rosario de los Mozos and Jes{\'u}s Fl{\'o}rez},
Perioperative Nimodipine and Postoperative Analgesia
It is demonstrated that increased morphine consumption after 12 h in postoperative patients receiving nimodipine is demonstrated, suggesting that, in patients undergoing knee replacement surgery, it has no adjunctive analgesic effect and may actually inhibit the analgesicEffect of morphine.
A Comparative Study with Oral Nifedipine, Intravenous Nimodipine, and Magnesium Sulfate in Postoperative Analgesia
In conclusion, the perioperative application of oral nifedipine, IV nimodIPine, or IV magnesium sulfate failed to decrease postoperative morphine requirements after colorectal surgery.
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers
Both a pharmacodynamic and pharmacokinetic interaction between morphine and GBP is revealed, leading to an increased analgesic effect of morphine + GBP, and the well tolerated combination of gabapentin and morphine may improve pain therapy.
Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain.
Ziconotide, combined with stable intrathecal morphine, may reduce pain and decrease systemic opioid use in patients with pain inadequately controlled by intratheCal morphine alone.
Enhanced analgesic effect of morphine-nimodipine combination after intraspinal administration as compared to systemic administration in mice
Addition of nimodipine to morphine potentiated the analgesic response of the latter when administer through the intraspinal route but not when administered through systemic route, which may be due to direct inhibitory effect of morphine and nimmodipine on neurons of superficial laminae of the spinal cord after binding to Μ-opioid receptors and L-type calcium channels respectively.
Nimodipine is more effective than nifedipine in attenuating morphine tolerance on chronic co-administration in the rat tail-flick test.
It is shown for the first time that nimodipine is more effective than nifedipine and that these L-CCBs continue to be effective, even 12 hr after administration in the tail-flick test.
Morphine in cancer pain management: a practical guide
Abstract. Morphine is the most practical and versatile analgesic for the relief of severe pain associated with advanced cancer. Information is available in the literature about its use in routine
Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure.
Gabapentin reduces opioid use during a 10-day buprenorphine detoxification procedure, and urine results showed a Drug × Time interaction, such that the probability of opioid-positive urines significantly decreased over time in the gabap Quentin versus placebo groups during Weeks 3 and 4.
Adjuncts to opioid therapy
  • F. Goldstein
  • Medicine
    The Journal of the American Osteopathic Association
  • 2002
Inadequate analgesia can become a suicidogen, ie, any factor that causes a patient to want to commit suicide, when patients are likely to request physicians to provide some method to accelerate their death.


[The clinical significance of drug interactions between opiates and calcium antagonists. A randomized double-blind study using fentanyl and nimodipine within the framework of postoperative intravenous on-demand analgesia].
To verify, in awake postoperative patients, whether nimodipine increased the analgesic efficacy of fentanyl, forty ASA I-II patients undergoing elective hysterectomy under standardized balanced anesthesia were investigated.
[Calcium antagonists in anesthesia. Additive analgesia using nimodipine in heart surgery].
The present data suggest an additive analgesic effect of nimodipine during surgery, and assumes that calcium is essential in pain perception and that decreased calcium would result in analgesia.
Low-dose fentanyl analgesia modified by calcium channel blockers in cardiac surgery.
It was concluded that nimodipine but not nifedipine administration can reduce fentanyl requirements during surgical procedures without influencing the quality of anaesthesia.
Calcium channel inhibitors suppress the morphine‐withdrawal syndrome in rats
The results suggest that Ca2+‐channel blockers suppress the behavioural and neurochemical expressions of morphine abstinence by a mechanism that differs from those of opioids or α2‐adrenoceptor agonists.
Tolerance to opioid analgesics: clinical aspects.
It is now clear that the loss of analgesic effects over time has a differential diagnosis, only one component of which is tolerance, and mechanisms related to the pain itself may have an important modulating effect on these phenomena.
Effect of Nifedipine on Morphine‐Induced Analgesia
The data indicate that Ca2+ is important in mediating the analgesic effects of opiates and suggest that calcium-receptor blockers might find a place in the treatment of pain.